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Non-ordered Mesoporous Silica Structure for Biomolecule Loading and Release

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
A non-ordered geometric mesoporous structure that provides for enhanced loading of antibodies such as IgG as compared to ordered mesoporous structures. This structure is formed by treating silica precursors at a hydrothermal aging temperature between 100 and 200 degrees C. This creates the non-ordered mesoporous structure. Biomolecules such as IgG can then be spontaneously loaded via non-covalent bonding within the as-made or functionalized mesoporous structure.
Lei, Chenghong (Richland, WA), Liu, Jun (Richland, WA), Li, Xiaolin (Richland, WA)
13/ 085,674
April 13, 2011
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY-SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under Contract DE-AC0576RLO1830 awarded by the U.S. Department of Energy as well as Grant R01GM080987 from the National Institutes of Health. The Government has certain rights in the invention.