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METHODS FOR SYSTEMATIC CONTROL OF PROTEIN STABILITY

United States Patent Application

20110130324
A1
View the Complete Application at the US Patent & Trademark Office
A Novel Antibody Engineering Platform to Improve Antibody Stability
Methods and compositions to control the stability of proteins with special emphasis on antibodies and proteins with antibody-like structures, e.g., having an "immunoglobulin-like" fold, are described. Controlling the stability facilities different applications for a protein with the same function, but different stability.
Stevens, Fred J. (Naperville, IL)
UCHICAGO ARGONNE, LLC (Chicago IL)
13/ 002,013
May 29, 2009
[0002] The United States Government has rights in this invention persuant to Contract No. DE-AC02-06CH11357 between the U.S. Department of Energy and UChicago Argonne, LLC, operator of Argonne National Library.