The various embodiments of the present disclosure relate generally to compositions and methods for the targeted cellular delivery of nanoparticles. More particularly, the various embodiments of the present invention are directed to the cellular delivery of nanoparticles tethered to a ligand by way of a poly(ethylene glycol) linkage, wherein the ligand demonstrates a binding specificity for a cellular target. In an exemplary embodiment, the ligand is tamoxifen and the cellular target is the estrogen receptor, which is upregulated in many breast cancer cells.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
 This invention was made with U.S. Government support under Centers of Cancer Nanotechnology Excellence Award U54CA119338 awarded by the National Cancer Institute, Grant No. DE-FG02-97 ER14799 awarded by the U.S. Department of Energy, and Grant No. CHE-0554668 awarded by the National Science Foundation. The U.S. Government has certain rights in the invention.