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Rapid and Continuous Analyte Processing in Droplet Microfluidic Devices

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed.
Strey, Helmut (Stony Brook, NY), Kimmerling, Robert (Shirley, NY), Bakowski, Tomasz (Levittown, NY)
The Research Foundation of State University of New York (Albany NY)
12/ 875,914
September 3, 2010
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with government support awarded by the U.S. Department of Energy under Grant No. ER46323 and the National Science Foundation under Grant No. NSF-DMR-0606282. The government has certain rights in this invention.