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SERS-BASED, SINGLE STEP, REAL-TIME DETECTION OF PROTEIN KINASE AND/OR PHOSPHATASE ACTIVITY

United States Patent Application

20110046018
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
This invention provides novel compositions and methods for the detection, and/or quantification, of the presence and/or activity of one or more kinases and/or phosphatases. In certain embodiments this invention a device for the detection of kinase and/or phosphatase activity where the device comprises a Raman active surface comprising features that enhance Raman scattering having attached thereto a plurality of kinase and/or phosphatase substrate molecules.
Chen, Fanqing Frank (Moraga, CA), Liu, Gang L. (Berkeley, CA), Ellman, Jonathan A. (Oakland, CA)
12/ 746,158
December 23, 2008
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This work was supported in part by Grant No: DE-AC02-05CH11231 from the U.S. Department of Energy. The Government of the United States of America has certain rights in this invention.