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NUCLEOTIDE CAPACITANCE MEASUREMENT FOR LOW COST DNA SEQUENCING

United States Patent Application

20110037486
A1
View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Low-cost, Rapid DNA Sequencing Technique
High frequency capacitance measurement on a single strand of deoxyribonucleic acid (DNA) or a ribonucleic acid (RNA) is employed to provide identification of the nucleotides in the strand. Effect of variations in the capacitance of nucleotides can be minimized by employing statistical quantities generated from multiple measurement values on a strand of DNA or RNA nucleotides, or by employing a program that positively identifies a large capacitance nucleotide upon detection of a large capacitance. Capacitance data on a DNA strand can be used as a criterion for identifying the DNA sequence in conjunction with other methods for identifying the DNA sequence.
Zhang, Xiaoguang (Oak Ridge, TN), Lu, Jun-Qiang (Mayaguez, PR)
UT-BATTELLE, LLC (Oak Ridge TN)
12/ 848,407
August 2, 2010
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This invention was made with United States government support under Prime Contract No. DE-AC05-00OR22725 awarded by the U.S. Department of Energy. The United States government has certain rights in this invention.