Skip to Content
Find More Like This
Return to Search

IMPRINTED GENES AND DISEASE

United States Patent Application

20110014607
A1
View the Complete Application at the US Patent & Trademark Office
Methods for identifying imprinted genes. In some embodiments, the methods comprise (a) providing a first data set comprising a plurality of nucleic acid sequences, wherein the nucleic acid sequences comprise genomic DNA sequences corresponding to a plurality of genes known to be imprinted in the subject; (b) providing a second data set comprising a plurality of nucleic acid sequences, wherein the nucleic acid sequences comprise genomic DNA sequences corresponding to a plurality of genes known not to be imprinted in the subject; (c) identifying one or more features that by themselves or in combination are differentially present or absent from the first data set as compared to the second data set; and (d) applying the one or more features to a test data set comprising a plurality of genomic DNA sequences which correspond to one or more genes for which the imprinting status is unknown to thereby identify an imprinted gene in a subject. The presently disclosed subject matter also provides methods for identifying a feature in a subject with respect to an imprinted gene and methods for detecting a presence of or a susceptibility to a medical condition associated with parent-of-origin dependent monoallelic expression in a subject.
Jirtle, Randy L. (Durham, NC), Hartemink, Alexander J. (Durham, NC), Luedi, Philippe P. (Basel, CH)
12/ 517,952
December 6, 2007
GOVERNMENT INTEREST [0002] This presently disclosed subject matter was made with U.S. Government support under Grant Nos. R01-ES008823 and R01-ES015165 awarded by the National Institutes of Health and Grant No. DE-FG02-05ER64101 from the Department of Energy. Thus, the U.S. Government has certain rights in the presently disclosed subject matter.