Skip to Content
Find More Like This
Return to Search

DIAGNOSIS AND TREATMENT OF CONGENITAL HEART DEFECTS USING NELL1

United States Patent Application

20110002893
A1
View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
The present invention provides diagnostic methods for detecting congenital heart defects, or increased risk thereof, based on the Nell1 gene, RNA and protein. The methods include obtaining a biological sample and assessing the presence of a mutation in the Nell1 gene, RNA or protein. The presence of a mutation in the Nell1 gene, RNA or protein can be assessed by determining the levels of Nell1 gene, RNA or protein in the biological sample. The present invention further provides therapeutic methods for treating congenital heart defects based on the Nell1 gene. RNA and protein.
Culiat, Cymbeline T. (Oak Ridge, TN)
UT-BATTELLE, LLC (Oak Ridge TN)
12/ 611,292
November 3, 2009
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] This invention was made with Government support under Contract No. DE-AC05-00OR22725 between the United States Department of Energy and UT-Battelle, LLC. The Government has certain rights in this invention.