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Identification And Use Of Genes Encoding Amatoxin And Phallotoxin

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms. In particular, the present invention relates to using genes and proteins from Amanita species encoding Amanita peptides, specifically relating to amatoxins and phallotoxins. In a preferred embodiment, the present invention also relates to methods for detecting Amanita peptide toxin genes for identifying Amanita peptide-producing mushrooms and for diagnosing suspected cases of mushroom poisoning. Further, the present inventions relate to providing kits for diagnosing and monitoring suspected cases of mushroom poisoning in patients.
Hallen, Heather E. (East Lansing, MI), Scott-Craig, John S. (East Lansing, MI), Walton, Jonathan D. (East Lansing, MI), Luo, Hong (East Lansing, MI)
Michigan State University
12/ 268,229
November 10, 2008
GOVERNMENT INTERESTS [0002] This invention was made in part with government support under grant ER20021, from the United States Department of Energy. As such, the United States Government has certain rights in the invention.