An agent for stimulating bone healing including isolated lysophosphatidic acid (LPA) and a hydrogel. A method of enhancing bone healing including identifying a damaged area of a bone and administering an agent comprising lysophosphatidic acid (LPA) is administered to the damaged area of the bone. A method of increasing bone regrowth. A subject is identified having a bone injury and lysophosphatidic acid (LPA) is administered to the subject.
GOVERNMENT RIGHTS STATEMENT
 This invention was made with Government support under contract DE-AC0676RLO1830 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.