Herein are described methods and tools for acquiring accurately co-registered PET and TRUS images, as well as the construction and use of PET-TRUS prostate phantoms. Ultrasound imaging with a transrectal probe provides anatomical detail in the prostate region that can be accurately co-registered with the sensitive functional information from the PET imaging. Imaging the prostate with both PET and transrectal ultrasound (TRUS) will help determine the location of any cancer within the prostate region. This dual-modality imaging should help provide better detection and treatment of prostate cancer. Multi-modality phantoms are also described.
STATEMENT OF GOVERNMENTAL SUPPORT
 This invention was made during work supported in part under Contract No. DE-AC02-05CH11231 awarded by the Office of Biological and Environmental Research, Medical Science Division, U.S. Department of Energy, in part under grant numbers DAMD17-02-1-0081 and W81XWH-07-1-0020 awarded by the Department of Defense, in part under grant numbers R01-EB-00194 and R01-HL-071253 awarded by the National Institute for Biomedical Imaging and Bioengineering,. The government has certain rights in this invention.