Disclosed are diagnostic methods for oral diseases such as oral cancer. In the methods, expression data of a plurality of genes associated with an oral disease is examined and compared to signature expression profile indicative of an oral disease. Also disclosed are systems, methods and kits for allowing a dentist to provide for detection of oral disease at the point of patient care.
 Work described herein was funded, in whole or in part, by Grant No. DE-FG02-94ER-14487 and DE-FG02-99ER-15015 from the Engineering Research Program of the Office of Basic Energy Science at the Department of Energy, and by Grant No. 1-RO1-DK58533-01 from NIH. The United States government has certain rights in the invention.