The present invention provides a sensor system kit for detecting an analyte, consisting essentially of: a nucleic acid enzyme, wherein the nucleic acid enzyme cleaves a substrate in the presence of the analyte; the substrate for the nucleic acid enzyme, comprising a polynucleotide; an aggregator; and particles.
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
 The subject matter of this application may have been funded in part by the National Science Foundation (DMI-0328162 and DMR-0117792), the Department of Defense (DAAD19-03-1-0227), the Office of Science (BER), the U.S. Department of Energy (DEFG02-01-ER63179) and by the National Institute of Health (Small Business Innovation Research (SBIR) Phase I grant, Grant No. ES014125). The federal government may have certain rights in this invention.