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Biocompatible hydrogel bone-like composites

United States Patent Application

20040161444
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A template-driven biomineralization process for making three-dimensional bonelike composites having direct and extensive mineral-substrate contact which provides high adhesion strength. The in situ generation of sufficient amounts of surface and interior carboxylates, through an increase in pH, serves as nuclear binding sites for mineral ions to promote high affinity 2-dimensional mineral growth at the substrate-mineral interface. The substrate for the bonelike composites is a hydrogel scaffold comprised of a polymerized base monomer having hydrolyzable ester side chains, crosslinked with a co-monomer and crosslinker. Hydrolysis of the ester containing side chains is preferably mediated by thermo-decomposition of urea.
Song, Jie (Fremont, CA), Bertozzi, Carolyn R. (Berkeley, CA), Saiz, Eduardo (Berkeley, CA)
The Regents of the University of California (Oakland CA)
10/ 740,739
December 18, 2003
[0002] This invention was made during work supported by U.S. Department of Energy under Contract No. DE-AC03-76SF00098. The government has certain rights in this invention.