Methods and compositions for directly selecting a nucleic acid sequence that confers resistance to an inhibitory compound are provided. Methods and compositions for decontaminating contaminated substances are provided. Microorganisms having resistance to an inhibitory compound are also provided.
STATEMENT OF GOVERNMENT INTERESTS
 This invention was made with Government support under DE-FG02-03ER63445 (T-103693) awarded by the U.S. Department of Energy. The Government has certain rights in the invention.