Skip to Content
Find More Like This
Return to Search

SURFACE-ENHANCED RAMAN SCATTERING (SERS) BASED NANOPARTICLE COMPOSITES

United States Patent Application

20100075339
A1
View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Nanoparticle composites and method of use thereof for simultaneously sensing and probing a biological system, comprising providing a nanoparticle composite comprising a nanoparticle comprising a core and a shell; a first ligand bound to the nanoparticle, said first ligand capable of sensing pH; a second ligand bound to the nanoparticle, said second ligand distinct from said first ligand and capable of binding to a target; and bringing the nanoparticle composite into contact with the biological system to produce a first and a second pH-dependent signal; and analyzing the first or the second signal by means of surface-enhanced Raman spectroscopy.
Rector, Kirk D. (Santa Cruz, NM), Nowak-Lovato, Kristy L. (Los Alamos, NM)
LOS ALAMOS NATIONAL SECURITY, LLC (Los Alamos NM)
12/ 534,612
August 3, 2009
STATEMENT OF FEDERAL RIGHTS [0002] The United States government has rights in this invention pursuant to Contract No. DE-AC52-06NA25396 between the United States Department of Energy and Los Alamos National Security, LLC for the operation of Los Alamos National Laboratory.