The coating of silicon surfaces is described, including but not limited to coating silicon surfaces with biomolecules such as biotin and avidin. Silicon surfaces are made with a monolayer of the protein streptavidin and these surfaces are then used as supports for reactions, including but not limited to nucleic acid hybridization.
 This application for patent under 35 U.S.C. 111(a) claims priority to Provisional Application Ser. No. 60/050,662, filed Jun. 24, 1997 under 35 U.S.C. 111(b). This invention was made with Government Support under Contract Number DE-FG02-93ER61656 awarded by the Department of Energy. The government has certain rights in the invention.