The present invention provides functionalized mesoporous microspheres comprising a microsphere including surface mesopores; a lipid bilayer covering at least a portion of the microsphere; and enclosed mesoporous spaces comprising the surface mesopores and respective portions of the lipid bilayer.
 The United States Government has rights in this invention pursuant to: Grant Nos. EEC-0210835 and MCB-9907611 from the National Science Foundation; Grant No. F49620-01-1-0168, from the Air Force Office of Scientific Research; Grant No. GM60799/EB00264 from the National Institutes of Health; and Grant No. 00-01-205-5 from the U.S. Department of Energy through the U.S./Mexico Materials Corridor Initiative. The government may have certain rights in this invention.