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Peptides for facilitating composite receptor expression and translocation of macromolecules

United States Patent Application

20030170826
A1
View the Complete Application at the US Patent & Trademark Office
The invention relates to compositions and methods for expressing a composite receptor on the cell surface. The composite receptor can be integrated into a cell membrane via a fusion peptide which includes a cell penetrating domain linked to a transmembrane domain. In a preferred embodiment, the composite receptor further comprises a ligand binding domain. In yet another embodiment the invention relates to compositions and methods for translocating a nucleic acid or other molecule across the cell membrane into the cell. In a preferred embodiment, the nucleic acid or other molecule is linked to a fusion peptide comprising an adapter domain which is linked to a cell penetrating domain.
Rabinovich, Peter (Madison, CT), Bray-Ward, Patricia (Madison, CT), Ward, David C. (Madison, CT)
10/ 061,607
February 1, 2002
[0002] This invention was supported in part using funds obtained from the U.S. Government (department of Energy, Grant No. DE/FG02/00ER/63058). The U.S. Government may therefore have certain rights in this invention.