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Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable

United States Patent Application

20030157509
A1
View the Complete Application at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
This invention relates to using customized oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals that are interpreted as a unit. Because of an improved method of hybridizing oligonucleotides from samples to microchips, microchips are reusable and transportable. For field study, portable laser or bar code scanners are suitable.
Mirzabekov, Andrei (Darien, IL), Guschin, Dmitry Y. (Rockville, MD), Chik, Valentine (Woodridge, IL), Drobyshev, Aleksei (Elektrosol, RU), Fotin, Alexander (Cambridge, MA), Yershov, Gennadiy (Hinsdale, IL), Lysov, Yuri (US)
10/ 212,476
August 5, 2002
[0002] The U.S. Government has rights to the invention pursuant to Contract W-32-109-ENG between the U.S. Department of Energy and the University of Chicago representing (Argonne National Laboratory).